Metipred

Endocrine diseases

• Primary and secondary adrenal insufficiency (drugs of choice - hydrocortisone or cortisone; if necessary, synthetic analogues may be used in combination with mineralocorticoids; the addition of mineralocorticoids is of particular importance in pediatrics).
• Congenital adrenal hyperplasia.
• Chronic and subacute thyroiditis.
• Hypercalcemia in the setting of cancer.

Non-endocrine diseases

1. Musculoskeletal diseases (including rheumatic)
   (as additional therapy, briefly, for withdrawal from an acute condition or in case of recrudescence)
   • Psoriatic arthritis.
   • Rheumatoid arthritis, including juvenile rheumatoid arthritis (in some cases, low-dose supporting therapy may be required).
   • Ankylosing spondylitis.
   • Acute and subacute bursitis.
   • Acute nonspecific peritendinitis.
   • Acute urarthritis.
   • Posttraumatic osteoarthritis.
   • Synovitis in the presence of osteoarthritis.
   • Epicondylitis.
2. General connective tissue diseases
   (during exacerbation or, in some cases, as supporting therapy)
   • Acute rheumatic heart disease.
   • Systemic lupus erythematosus.
   • Systemic dermatomyositis (polymyositis).
   • Rheumatic polymyalgia.
   • Giant cell arteritis.
3. Skin diseases
   • Pemphigus.
   • Herpetiform bullous dermatitis.
   • Severe erythema multiforme (Stevens-Johnson syndrome).
   • Exfoliative dermatitis.
   • Mycosis fungoides.
   • Severe psoriasis.
   • Severe seborrheic dermatitis.
4. Allergic reactions
   (severe or disabling conditions in case of which conventional therapy is ineffective)
   • Seasonal or year-round allergic rhinitis.
   • Serum disease.
   • Bronchial asthma.
   • Hypersensitivity reactions to drugs.
   • Contact dermatitis.
   • Atopic dermatitis.
5. Eye diseases (severe acute and chronic allergic and inflammatory processes with damage to the eyes and their appendages)
   • Allergic marginal ring ulcer of the cornea.
   • Herpes zoster with eye damage.
   • Inflammation of the anterior eye.
   • Diffuse posterior uveitis and choroiditis.
   • Sympathetic ophthalmia.
   • Allergic conjunctivitis.
   • Keratitis.
   • Chorioretinitis.
   • Optic neuritis.
   • Iritis and iridocyclitis.
6. Diseases of the respiratory system
   • Symptomatic sarcoidosis.
   • Leffler syndrome, not responding to therapy by other means.
   • Berylliosis.
   • Peracute or disseminated tuberculosis in combination with appropriate antituberculous chemotherapy.
   • Aspiration pneumonitis.
7. Hematologic diseases
   • Idiopathic thrombocytopenic purpura in adults.
   • Secondary thrombocytopenia in adults.
   • Acquired (autoimmune) haemolytic anaemia.
   • Erythroblastopenia (erythrocytic anaemia).
   • Congenital (erythroid) hypoplastic anaemia.
8. Cancer (as supportive care)
   • Leukemia and lymphoma in adults.
   • Acute leukemia in children.
9. Edema syndrome
   • For diuresis stimulation and to achieve remission of proteinuria in patients with nephrotic syndrome without uremia, or nephrotic syndrome of idiopathic type, or caused by systemic lupus erythematosus.
10. Gastrointestinal diseases (to withdraw the patient from a critical condition)
    • Ulcerative colitis.
    • Regional enteritis.
11. Nervous system
    • Exacerbations of multiple sclerosis.
    • Cephaledema secondary to tumor.
12. Other indications
    • Tuberculous meningitis with subarachnoid block or with a threat of block (in combination with appropriate antituberculous chemotherapy).
    • Trichinellosis with damage to the nervous system or myocardium.
13. Organ transplantation